WD40 domain divergence is important for functional differences between the fission yeast Tup11 and Tup12 co-repressor proteins.
We have previously demonstrated that subsets of Ssn6/Tup target genes have distinct requirements for the Schizosaccharomyces pombe homologs of the Tup1/Groucho/TLE co-repressor proteins, Tup11 and Tup12.The very high level of divergence in the histone interacting repression domains of the two proteins suggested that determinants distinguishing Tup1